- 1920′s biological effects of high intensity ultrasound are demonstrated
- 1950′s Indianapolis HIFU pioneer Fry studies Hifu for brain disorders
- 1970′s Indianapolis early studies with use in prostate
- 2000′s start of clinical usage of Hifu for prostate cancer and development of international sites for treatment of prostate cancer with the Sonablate 500 by USHIFU
